Cognitive impairment in clinical hypothyroidism

Background Hypothyroidism is a highly prevalent disease and has been associated with deficits in cognitive performance. It generally accepted that these could be related to psychiatric symptoms. Hormone replacement therapy the gold standard treatment for primary hypothyroidism, it appears effective correcting serum thyrotropin (TSH) values thyroid hormone profile. Despite correction of hormonal profile, some patients continue manifest The possibility restitution performance after achieving euthyroidism still matter controversy, without having reports making any comparisons patient himself before treatment. Method Prospective, experimental study, own individual as control. All subjects over 18 years age who consult Endocrinology Service Churruca Visca Hospital whom diagnosis clinical hypothyroidism made, defined by TSH greater than 10 mIU/L, will included until sample size completed. (N) 78 patients, calculated an estimated prevalence failure 40%, including meet criteria impairment those who, even meeting criteria, show detriment their best performance, alpha error 0.05 beta 0.2, assuming 50% improvement These referred Cognitive Neurology Section same complete evaluation depression axiety scales. 12 months first evaluation, achieved, repeated. comparison made subject’s evaluating remission installed, differences impairment, comparing subject Result We expect find improvements between hypothyroidsm Conclusion Clinical treatable cause failure. Although usually present start treatment, different failures once achieved.